A variant insulin promoter in non-insulin-dependent diabetes mellitus.

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A variant insulin promoter in non-insulin-dependent diabetes mellitus.

To test the hypothesis that alterations in regulatory regions of the insulin gene occur in a subset of patients with non-insulin-dependent diabetes mellitus (NIDDM), the promoter region was studied by polymerase chain reaction (PCR) amplification directly from genomic DNA, followed by high-resolution polyacrylamide gel electrophoresis under nondenaturing conditions. By using this method a previ...

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Non-insulin-dependent diabetes mellitus (NIDDM) occurs predominantly after the age of 50 years but is not easy to distinguish from late onset insulin-dependent diabetes. It is likely that misclassification is rare in a Caucasian population. Whilst NIDDM is widely believed to be genetically determined, recent epidemiological observations have consistently revealed statistical associations betwee...

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However, it has also been recognized that the treatment of NIDDM patients frequently is inadequate even in those patients who should achieve the target range. In a recent population based cohort the median of glycosylated haemoglobin was 10.2% in NIDDM patients treated with diet or oral hypoglycemic agents (OHA) and 11.8% in NIDDM patients who used insulin. In a 5 year follow-up study of NIDDM ...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1992

ISSN: 0021-9738

DOI: 10.1172/jci115754